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Primary cryptococcal prostatitis and correlation with serum prostate specific antigen in a renal transplant recipient
Tahseen J Siddiqui1, Tanveer Zamani, Jorge P Parada
1Department of Medicine, Jackson Park Hospital & Medical Center, 7531 South Stony Island Avenue, Chicago, IL 60649, USA.
The Journal of Infection
|October 19, 2005
Summary
This study reports the first case of primary cryptococcal prostatitis in a renal transplant patient. Successful treatment with fluconazole highlights its efficacy for this rare fungal infection.
Area of Science:
- Infectious Diseases
- Urology
- Nephrology
Background:
- Prostate gland is an uncommon site for primary Cryptococcus neoformans infection.
- Prostatic sequestration of C. neoformans can occur after disseminated infection.
- The role of prostate-specific antigen (PSA) in cryptococcal prostatitis is not well-defined.
Observation:
- A renal transplant recipient presented with an asymmetrically enlarged prostate and elevated serum PSA.
- Diagnosis was confirmed by prostatic biopsy showing C. neoformans and positive blood cultures (fungemia).
- This represents the first reported case of primary cryptococcal prostatitis.
Findings:
- The patient received a prolonged course of fluconazole for treatment.
- The patient remained disease-free for over 28 months post-treatment.
- Literature review since 1946 on cryptococcal prostatitis and PSA correlation was performed.
Implications:
- This case expands the understanding of C. neoformans manifestations in immunocompromised patients.
- Highlights the importance of considering fungal prostatitis in transplant recipients with elevated PSA.
- Suggests fluconazole as an effective treatment for cryptococcal prostatitis.
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