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The kinetics of interactions between fecapentaene-12 and DNA
Mohammad Zaman Kassaee1, Ahmad Reza Bekhradnia
1Department of Chemistry, Tarbiat Modarres University, Pole-Gisha, Tehran, Iran. kassaeem@modares.ac.ir
Journal of Bioscience and Bioengineering
|October 20, 2005
Abstract:
Fecapentaene-12 (Fp-12) is a potent colon cancer mutagen, which interacts with DNA. In this study, the kinetics of its interactions with DNA is investigated. Various pHs are used. Three first-order rates are observed at each pH. This suggests that interaction between Fp-12 and DNA occurs through three different mechanisms.
