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Updated: Aug 15, 2026

Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
Optimal H infinity insulin injection control for blood glucose regulation in diabetic patients
Frederick Chee1, Andrey V Savkin, Tyrone L Fernando
1School of Electrical, Electronic and Computer Engineering, University of Western Australia, Crawley, WA 6009, Australia. chee-hf@ee.uwa.edu.au
Abstract:
The theory of H infinity optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.
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