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Synthesis of farnesol isomers via a modified Wittig procedure
José S Yu1, Troy S Kleckley, David F Wiemer
1Department of Chemistry, University of Iowa, Iowa City, 52242, USA.
Abstract:
[structure: see text] The four olefin stereoisomers of farnesol have been synthesized from readily available nerylacetone or commercial geranylacetone. A new variation on the use of beta-oxido ylides favored the (2Z)-stereoisomers, whereas the (2E)-isomers were obtained through a classical Horner-Wadsworth-Emmons condensation with triethyl phosphonoacetate and reduction of the resulting ester.
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