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Changes in alkaline phosphatase and 5'-nucleotidase multiple forms after surgical management of biliary obstruction
1Laboratorio Central, Hospital General de Galicia, Santiago de Compostela, Spain.
Clinical Chemistry
|July 1, 1992
Abstract:
Serial measurements of alkaline phosphatase and 5'-nucleotidase multiple forms in two patients undergoing surgical procedures to release biliary obstruction suggested an inverse relationship between high-M(r) isoforms and serum bile acids concentrations. Furthermore, the study of several groups of patients with cholestatic disorders confirmed this inverse correlation. Mechanisms responsible for these observations are discussed.