Related Experiment Video
Updated: Aug 15, 2026

Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
[Angioedema due to ACE inhibitors and AT(1) receptor antagonists]
M-C Hellebrand1, G Kojda, T K Hoffmann
1Hals-, Nasen- und Ohrenklinik, Universitätsklinikum Düsseldorf.
Abstract:
Acute drug-induced angioedema is a non-pruritic swelling of subcutaneous and submucosal tissue. It most occur occurs the mouth and larynx as well as lips and eyelids; less often other skin regions or even the gut can be involved. ACE inhibitor (ACEi)- induced angioedema typical occurs after several years on medication. A 72-year-old woman developed recurrent ACEi-induced angioedema. The drug was stopped and she received an AT(1)-receptor antagonist as an alternative antihypertensive. This medication also led to angioedema, which was not immediately recognized as medication-associated. AT(1)-receptor antagonists are not suitable alternatives for ACEi because they also carry an increased risk for inducing angioedema.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Antihypertensive Drugs: Angiotensin II Receptor Blockers
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Antihypertensive Drugs: Direct Renin Inhibitors
Antihypertensive Drugs: Action of β1 Blockers
Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...