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Oesophageal candidiasis after omeprazole therapy
1Medical Unit No. 1, Freeman Hospital, High Heaton, Newcastle-upon-Tyne.
Gut
|June 1, 1992
Summary
Omeprazole therapy may increase the risk of oesophageal candidiasis by reducing gastric acid. Stopping omeprazole and using anti-candidal treatment rapidly resolved infections in two patients.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Proton pump inhibitors like omeprazole are widely used to reduce gastric acid secretion.
- Oesophageal candidiasis is an opportunistic fungal infection that can affect the esophagus.
Observation:
- Two patients on omeprazole therapy were incidentally diagnosed with oesophageal candidiasis during endoscopy.
- No other predisposing factors for candidiasis were identified in these patients.
Findings:
- Oesophageal candidiasis resolved rapidly upon discontinuation of omeprazole and initiation of anti-candidal therapy.
- The findings suggest a potential protective role of gastric acid and physiological acid reflux against Candida infection in the esophagus.
Implications:
- Gastric acid suppression may be a risk factor for developing oesophageal candidiasis.
- Clinicians should consider the potential for fungal infections in patients on long-term proton pump inhibitor therapy.
- Further research is warranted to elucidate the relationship between acid suppression and oesophageal candidiasis.
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