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Low yield for extended reading of patch tests with topical corticosteroids
Mark D P Davis1, Donna M Richardson, Sara A Farmer
1Department of Dermatology and the Division of Biostatistics, Mayo Clinic, Rochester, MN, USA.
Extended readings for corticosteroid patch tests rarely revealed new reactions. In this study, only two delayed reactions were observed, suggesting limited value for extended follow-up in corticosteroid allergy testing.
Area of Science:
- Dermatology
- Allergy and Immunology
- Contact Dermatitis
Background:
- Patch testing is crucial for diagnosing allergic contact dermatitis.
- Extended readings (day 7+) may detect delayed hypersensitivity reactions.
- Previous reports suggest up to 30% of reactions are missed without extended readings.
Purpose of the Study:
- To evaluate the utility of extended readings for corticosteroid patch tests.
- To determine the frequency of delayed reactions to corticosteroids.
Main Methods:
- Retrospective review of patients patch tested with corticosteroids.
- Data collected from April 2001 to June 2004.
- Analysis of reactions at standard (day 5) and extended (day 7+) readings.
Main Results:
- 135 patients underwent 1,656 corticosteroid patch tests.
- Five positive reactions were noted by day 5.
- Two additional positive reactions to budesonide were detected at extended readings (day 7 and day 9).
Conclusions:
- Extended readings for corticosteroid patch tests yielded only two additional positive reactions.
- The value of extended readings for this specific allergen series appears limited.
- Further investigation may be warranted for specific corticosteroid compounds.
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