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Unraveling the molecular pathways that regulate early telencephalon development
1Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Current Topics in Developmental Biology
|October 26, 2005
Summary
The developing telencephalon forms the cerebral hemispheres from a sheet of neuroepithelial cells. Research is uncovering the molecular pathways that instruct these cells for patterning and development.
Area of Science:
- Neuroscience
- Developmental Biology
Background:
- The telencephalon, the most anterior part of the developing central nervous system, originates as a simple sheet of neuroepithelial cells.
- This neural sheet undergoes complex patterning and morphological partitioning to form the adult cerebral hemispheres.
Purpose of the Study:
- To investigate the molecular mechanisms underlying the patterning of the telencephalic neuroepithelium.
- To understand how precursor cells are instructed to generate diverse neural cell types and regulate proliferation, differentiation, and cell death during cerebral hemisphere formation.
Main Methods:
- This abstract does not specify methods.
Main Results:
- This abstract does not specify results.
Conclusions:
- The molecular pathways governing telencephalic patterning and cerebral hemisphere formation are actively being elucidated.