Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Libman-sacks endocarditis and primary antiphospholipid syndrome.

Carlos Gonzalez-Juanatey1, Miguel A Gonzalez-Gay

  • 1Division of Cardiology, Hospital Xeral-Calde, Lugo, Spain. carlosjuanatey@secardiologia.es

The Journal of Heart Valve Disease
|October 26, 2005
PubMed
Summary

Antiphospholipid syndrome (APS) can cause cardiac failure and Libman-Sacks endocarditis. Aggressive treatment including anticoagulation led to partial recovery of mitral regurgitation in one patient.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiovascular-Kidney-Metabolic syndrome predicts the development of cardiovascular events in patients with rheumatoid arthritis: a 10-years prospective analysis from the CARMA cohort.

Seminars in arthritis and rheumatism·2026
Same author

Ventricular Tachycardia With a Narrow QRS Complex: When the Improbable Is Possible.

JACC. Case reports·2026
Same author

Giant cell arteritis and atherosclerosis: coexistence or causality?

Clinical and experimental rheumatology·2026
Same author

Age-Related Differences in the Clinical Profile and Management of Atrial Fibrillation: Results from the Multicentre REGUEIFA Registry.

Journal of clinical medicine·2026
Same author

The Impact of Introducing Sacubitril/Valsartan and SGLT2 Inhibitors in a Cohort of Patients with Reduced-Ejection-Fraction Heart Failure: A Real-Life Observational Study.

Journal of clinical medicine·2026
Same author

Bidirectional ventricular tachycardia and cardiogenic shock caused by acute haemorrhagic necrosis of pheochromocytoma: a case report.

European heart journal. Case reports·2026

Area of Science:

  • Cardiology
  • Rheumatology
  • Internal Medicine

Background:

  • Antiphospholipid syndrome (APS) is an autoimmune disorder associated with an increased risk of thrombosis and pregnancy-related complications.
  • Cardiac involvement, including valvular heart disease and endocarditis, is a recognized but often underdiagnosed complication of APS.

Observation:

  • A case of cardiac failure in a female patient with primary APS, diagnosed eight years prior, is presented.
  • The patient exhibited Libman-Sacks endocarditis, a characteristic manifestation of APS affecting heart valves.

Findings:

  • A 12-month treatment regimen combining aggressive anticoagulation and medical management for cardiac failure resulted in partial regression of severe mitral regurgitation.
  • This suggests a potential for therapeutic intervention to mitigate valvular dysfunction in APS patients.

Related Experiment Videos

Implications:

  • Close clinical and echocardiographic surveillance is crucial for patients with APS and heart valve disease.
  • Optimal management, encompassing aggressive anticoagulation and specific heart failure therapies, may significantly reduce the severity of valve dysfunction.