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Updated: Dec 31, 2025

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
A quadricuspid aortic valve in a patient with neurofibromatosis type 1
James Coulston1, Joyce Thekkudan, Mohamed F Ibrahim
1Department of Cardiothoracic Surgery, University Hospital of Wales, Heath Park, Cardiff, UK. jamescoulston@hotmail.com
Abstract:
Quadricuspid aortic valve is a rare cardiovascular abnormality. Herein is described the case of a male patient with neurofibromatosis type 1 (NF1) who was found to have a quadricuspid aortic valve causing severe aortic regurgitation. Although congenital cardiac malformations have been described in patients with NF1, to the best of the present authors' knowledge this is the first time that a quadricuspid valve in a patient with neurofibromatosis has been described.
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