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Updated: Aug 15, 2026

Isolation and Enrichment of Liver Progenitor Subsets Identified by a Novel Surface Marker Combination
Published on: February 18, 2017
[Liver repopulation strategies]
Hélène Gilgenkrantz1, Jacques-Emmanuel Guidotti, Claudia Mitchell
1Institut Cochin, U.567 INSERM, UMR8104, Université R. Descartes, 24 rue du Fg St Jacques, 75014 Paris.
Abstract:
Hepatocytes have the unique capacity to self-renew and repair the liver ad integrum when stimulated to proliferate by liver injury. However, transplantation of isolated hepatocytes is usually not sufficiently efficient for therapeutic purposes. We conferred a survival advantage on transplanted hepatocytes and showed that they were able to repopulate almost the entire mouse liver after repeated injury. In contrast, we found that bone marrow stem cell transdifferentiation was inadequate for therapeutic liver regeneration. Current data on liver stem cells will be discussed.

