Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Resolving fiber crossing using advanced fast marching tractography based on diffusion tensor imaging.

P Staempfli1, T Jaermann, G R Crelier

  • 1Institute for Biomedical Engineering, ETH and University Zurich, Gloriastrasse 35, CH-8092 Zurich, Switzerland. staempfli@biomed.ee.ethz.ch

Neuroimage
|October 27, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromosomal fusions shaped the genome of the greater hornwrack bryozoan (Flustra foliacea) (Linnaeus, 1758).

The Journal of heredity·2026
Same author

Power stabilization of a terahertz-frequency quantum-cascade laser using a photonic-integrated modulator.

Optics express·2024
Same author

Voxel-Based Morphometry-from Hype to Hope. A Study on Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy.

AJNR. American journal of neuroradiology·2020
Same author

Gas spectroscopy through multimode self-mixing in a double-metal terahertz quantum cascade laser.

Optics letters·2018
Same author

Silver-based surface plasmon waveguide for terahertz quantum cascade lasers.

Optics express·2018
Same author

Extraction-controlled terahertz frequency quantum cascade lasers with a diagonal LO-phonon extraction and injection stage.

Optics express·2016
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
Same journal

Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory.

NeuroImage·2026
See all related articles

This study introduces a novel fast marching (FM) tractography method for brain imaging. The new technique accurately reconstructs white matter pathways, even at complex fiber crossings, improving upon existing methods.

Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Biomedical Engineering

Background:

  • Magnetic resonance diffusion tensor tractography (DTT) non-invasively visualizes brain white matter architecture.
  • Standard DTT struggles with complex fiber arrangements like axonal crossings due to tensor model limitations.
  • Accurate white matter reconstruction is crucial for understanding brain connectivity.

Purpose of the Study:

  • To develop a novel tractography method capable of resolving fiber crossings and tract branching.
  • To improve the accuracy of white matter trajectory reconstruction in heterogeneous fiber arrangements.
  • To enhance the capabilities of fast marching (FM) tractography for complex neural pathways.

Main Methods:

  • A new FM tractography approach incorporating information from the entire diffusion tensor was developed.

Related Experiment Videos

  • The FM speed function was adapted to local tensor characteristics to maintain directional accuracy at crossings.
  • Reduced discretization error by increasing the number of considered front evolution directions.

    • Main Results:

    • The proposed FM method successfully resolved fiber crossings and permitted trajectory branching in artificial and human brain data.
    • Demonstrated superior accuracy in reconstructing trajectories compared to standard FM and line propagation algorithms in the presence of interfering structures.
    • In vivo results showed accurate elucidation of major white matter pathways consistent with known anatomy.

    Conclusions:

    • The novel FM tractography method effectively handles complex white matter architectures, including multiple crossings and tract branching.
    • This technique offers improved accuracy and reliability for non-invasive brain white matter mapping.
    • The findings advance the potential of DTT for detailed neuroanatomical studies.