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Corneal keloid in Lowe syndrome
Salomon Esquenazi1, H Sprague Eustis, Haydee E Bazan
1Department of Ophthalmology, Neuroscience Center of Excellence, Louisiana State University, School of Medicine, 2020 Gravier Street, 3rd Floor, Suite B, New Orleans, LA 70112, USA.
Journal of Pediatric Ophthalmology and Strabismus
|October 28, 2005
Summary
This study details a rare corneal keloid in a child with Lowe syndrome following eye surgeries. Immunohistochemistry and alternative treatments for this condition are discussed.
Area of Science:
- Ophthalmology
- Genetics
- Pathology
Background:
- Lowe syndrome is a rare X-linked disorder affecting multiple organs, including the eyes.
- Ocular manifestations in Lowe syndrome can include cataracts and strabismus, often requiring surgical intervention.
Observation:
- A 3-year-old boy with Lowe syndrome developed an inferior corneal keloid after bilateral cataract surgery and strabismus surgery.
- The corneal keloid presented as a significant post-surgical complication.
Findings:
- The corneal keloid lesion was surgically resected.
- Immunohistochemistry analysis of the keloid specimen provided insights into its cellular composition.
- Alternative treatment modalities for managing corneal keloids in this rare context were evaluated.
Implications:
- This case highlights a rare but serious ocular complication in Lowe syndrome patients.
- Understanding the pathology of corneal keloids can inform future management strategies.
- Further research into effective treatments for corneal keloids in genetic disorders is warranted.