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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Disorders in the lungs-placenta system under conditions of experimental gestosis in rats
V V Myasnikova1, S P Lysenkov, P A Galenko-Yaroshevskii
1Krasnodar Affiliated Branch of Southern Bureau of Russian Academy of Medical Sciences; N. V. Karsanov National Research Center of Medical Biophysics and Introduction of New Biomedical Technologies, Tbilisi.
Abstract:
Study of the arteriovenous difference in hormone levels and hemostasis parameters in rats with experimental gestosis induced by hyper-sodium diet showed decreased production of progesterone, increased level of hydrocortisone (resultant from its increased production and additional release of the hormone by the lungs), hypercoagulation, and retarded fetal development. Involvement of the lungs into the maintenance of optimum rheological parameters of arterial blood and a relationship between the level of fetoplacental hormones and the function of pulmonary fibrinolytic filter were detected.

