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Evaluation of the platelet function analyzer (PFA-100) vs. the thromboelastogram (TEG) in the parturient
Y Beilin1, I Arnold, S Hossain
1Department of Anesthesiology, Mount Sinai School of Medicine of New York University, New York, NY 10029-6574, USA. yaakov.beilin@mountsinai.org
International Journal of Obstetric Anesthesia
|November 1, 2005
Summary
The closure time (CT) test does not correlate with platelet count or thromboelastogram (TEG) maximum amplitude (MA) in parturients. However, TEG MA strongly correlates with platelet count, suggesting TEG is superior for evaluating coagulation in thrombocytopenic parturients.
Area of Science:
- Hematology
- Obstetrics
- Coagulation Diagnostics
Background:
- The Platelet Function Analyzer (PFA-100) assesses platelet function via closure time (CT) using epinephrine (EPI) or adenosine 5'diphosphate (ADP).
- The Thromboelastogram (TEG) measures whole blood clotting, with maximum amplitude (MA) correlating to platelet count and function.
Purpose of the Study:
- To determine correlations between PFA-100 closure time (CT) and platelet count.
- To investigate associations between CT and TEG maximum amplitude (MA).
- To examine the relationship between platelet count and TEG MA in healthy term parturients.
Main Methods:
- Blood samples from 172 healthy term parturients were analyzed.
- Platelet count, PFA-100 closure time (CT-EPI and CT-ADP), and TEG maximum amplitude (MA) were measured.
Main Results:
- No significant correlation was found between CT-EPI or CT-ADP and platelet count.
- No significant correlation was observed between CT-EPI or CT-ADP and TEG MA.
- A significant positive correlation was detected between platelet count and TEG MA (r=0.33, P<0.001).
Conclusions:
- PFA-100 closure time does not correlate with platelet count or TEG MA in parturients.
- TEG MA shows a significant correlation with platelet count in this population.
- TEG may be a more reliable tool for assessing coagulation in parturients with thrombocytopenia.