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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...

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Related Experiment Video

Updated: Jun 26, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Advances in functional protein microarray technology.

Paul Bertone1, Michael Snyder

  • 1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. paul.bertone@yale.edu

The FEBS Journal
|November 3, 2005
PubMed
Summary
This summary is machine-generated.

Protein microarrays enable large-scale screening of protein interactions and functions. This technology facilitates disease marker discovery, toxicology studies, and pharmaceutical development by analyzing numerous proteins simultaneously.

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Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

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Related Experiment Videos

Last Updated: Jun 26, 2026

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

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Published on: May 4, 2012

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Published on: August 2, 2015

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06:01

Extracellular Protein Microarray Technology for High Throughput Detection of Low Affinity Receptor-Ligand Interactions

Published on: January 7, 2019

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Biotechnology

Background:

  • Advancements in high-throughput protein production and microarray technologies allow for dense, addressable protein arrays.
  • Current protein array applications predominantly utilize antibody arrays for high-throughput protein profiling.
  • The development of protein arrays offers an alternative approach using full-length, functional proteins from expression clone libraries.

Purpose of the Study:

  • To highlight the potential of protein-based microarrays for global biochemical activity observation.
  • To showcase the capability of screening hundreds or thousands of proteins simultaneously for various interactions.
  • To emphasize the broad applicability of protein arrays in research and development.

Main Methods:

  • Utilizing innovations in high-throughput protein production.
  • Employing advanced microarray surface technologies for high spatial density.
  • Constructing arrays of full-length, functional proteins from expression clone libraries.

Main Results:

  • Protein arrays enable the global observation of biochemical activities at an unprecedented scale.
  • Simultaneous screening of numerous proteins for protein-protein, protein-nucleic acid, and small molecule interactions is feasible.
  • The technology provides a powerful tool for comprehensive biological analysis.

Conclusions:

  • Protein-based microarrays represent a significant technological advancement with broad implications.
  • This technology holds immense potential for basic molecular biology research.
  • Applications include disease marker identification, toxicological response profiling, and pharmaceutical target screening.