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Stereotactic interstitial radiosurgery for cerebral metastases
William T Curry1, Garth Rees Cosgrove, Fred H Hochberg
1Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA. wcurry@partners.org
Journal of Neurosurgery
|November 4, 2005
Summary
The Photon Radiosurgery System (PRS) offers effective local control for brain metastases, comparable to surgery. This radiosurgery technique integrates diagnosis and treatment in a single procedure, improving patient outcomes.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Medical Physics
Background:
- Brain metastases present a significant challenge in oncology.
- Stereotactic biopsy is often used for diagnosis.
- Integrated diagnostic and therapeutic approaches are desirable.
Purpose of the Study:
- To review the treatment of brain metastases using the Photon Radiosurgery System (PRS).
- To discuss the indications, advantages, and limitations of PRS for intracranial tumors.
- To evaluate the efficacy and safety of PRS in treating cerebral metastases.
Main Methods:
- Retrospective review of patients with brain metastases treated with PRS (December 1992-November 2000).
- Analysis of clinical characteristics, treatment parameters, neuroimaging outcomes, and survival.
- Definition of local control as stabilization or diminution of tumor size on MRI.
Main Results:
- 72 lesions in 60 patients were treated; primary cancers included lung, melanoma, and renal cell carcinoma.
- Local disease control was achieved in 81% of tumors at a median follow-up of 6 months.
- 6-month and 12-month survival rates were 63% and 34%, respectively.
Conclusions:
- Photon Radiosurgery System (PRS) provides local control of cerebral metastases comparable to open resection and external stereotactic radiosurgery.
- The primary advantage of PRS is the integration of effective treatment with stereotactic biopsy.
- PRS offers a valuable option for combined diagnosis and treatment of brain metastases.