Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bacterial location in chronic sinusitis.

Anders Ebenfelt1

  • 1Department of Otorhinolaryngology, Head and Neck Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.

American Journal of Rhinology
|November 8, 2005
PubMed
Summary

Bacterial invasion of sinus tissue is not always the cause of chronic sinusitis. This study found little evidence of bacteria within the sinus lining, challenging common assumptions about this inflammatory condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Necrobacillosis in humans.

Expert review of anti-infective therapy·2011
Same author

Pivotal advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation.

Journal of leukocyte biology·2011
Same author

Mucosal secretion changes during radiotherapy in the oral cavity.

Clinical oral investigations·2007
Same author

Deep neck space infections remain a surgical challenge. A study of 72 patients.

Acta oto-laryngologica·2005
Same author

Bacterial adherence to mucosal epithelium in the upper airways has less significance than believed.

Journal of negative results in biomedicine·2003
Same author

Neutrophils are hyperactive in recurrent tonsillitis.

Acta oto-laryngologica·2002

Area of Science:

  • Otolaryngology
  • Microbiology
  • Immunology

Background:

  • Chronic sinusitis is often attributed to bacterial invasion of the sinus mucosa.
  • Previous biopsy studies have not confirmed bacterial presence in normal or moderately damaged epithelial layers.

Purpose of the Study:

  • To investigate the presence of bacterial invasion in the sinus mucosa of patients with chronic sinusitis.
  • To determine if bacterial invasion is a prerequisite for the inflammatory process in chronic sinusitis.

Main Methods:

  • Mucosal samples were obtained from six patients diagnosed with chronic sinusitis.
  • Transmission electron microscopy was employed to identify bacterial invasion and phagosome formation.

Main Results:

  • Bacterial phagocytosis, a sign of host response, was observed in only one of the six patients.
  • The remaining five patients showed no evidence of bacterial invasion or phagocytosis in their sinus mucosa.

Conclusions:

  • Bacterial invasion of the sinus mucosa is not a necessary or obligatory event in the development or maintenance of chronic sinusitis.
  • These findings suggest alternative mechanisms may be involved in the pathogenesis of chronic sinusitis.

Related Experiment Videos