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Related Experiment Videos

Fumonisin mycotoxicosis in broilers: performance and pathology.

T P Brown1, G E Rottinghaus, M E Williams

  • 1Department of Avian Medicine, College of Veterinary Medicine, University of Georgia, Athens 30605.

Avian Diseases
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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Feeding broiler chicks a diet contaminated with fumonisin B1 mycotoxin caused significant health issues, including diarrhea, reduced weight gain, liver damage, and rickets. Aluminosilicate supplementation did not prevent these adverse effects.

Area of Science:

  • Animal Science
  • Veterinary Pathology
  • Mycotoxicology

Background:

  • Fusarium moniliforme is a common fungal contaminant of grains.
  • Fumonisin B1 is a mycotoxin produced by Fusarium species with known toxicity.
  • Broiler chickens are susceptible to mycotoxin-induced health problems.

Purpose of the Study:

  • To investigate the toxicological effects of fumonisin B1 in broiler chickens.
  • To evaluate the efficacy of aluminosilicate as a counteracting agent against fumonisin B1 toxicity.

Main Methods:

  • Broiler chicks were fed a diet containing Fusarium moniliforme culture material with 300 mg/kg fumonisin B1 for two weeks.
  • Clinical signs, body weight, liver weight, and feed conversion were assessed.
  • Histopathological examination of tissues was performed.

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  • A separate group received simultaneous supplementation with 0.5% aluminosilicate.

    • Main Results:

    • Fumonisin B1 exposure resulted in diarrhea, a 19% reduction in body weight, and a 30% increase in relative liver weight.
    • Histological findings included multifocal hepatic necrosis, biliary hyperplasia, muscle necrosis, intestinal goblet-cell hyperplasia, and rickets.
    • Aluminosilicate supplementation did not alleviate the clinical signs or pathological lesions.

    Conclusions:

    • Fumonisin B1 causes significant clinical and pathological effects in broiler chickens.
    • The induced disease syndrome closely resembles viral enteritis.
    • Aluminosilicate is ineffective in mitigating fumonisin B1 toxicity in this model.