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Updated: Aug 15, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Spontaneous intestinal melanoma in dogs
Enrico P Spugnini1, Emanuele Dragonetti, Raffaele Murace
1SAFU Department, Regina Elena Cancer Institute, Rome, Italy. enrico.spugnini@tiscali.it
Abstract:
Primary melanoma of the gastrointestinal tract is a rare, highly malignant neoplasm that is associated with an unfavorable long-term prognosis. Animal studies are needed to further characterize this tumor and to develop new and more effective protocols. A spontaneous canine intestinal melanoma is described which, because of its local aggressive behavior and advanced stage, was not treatable with conventional strategies, thus being a potential candidate for investigational trials.
