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Updated: Aug 15, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Convenient access to new chiral ferroceno-(iso)quinolines
1Synthèse Organométallique et Réactivité, UMR CNRS-UHP 7565, Faculté des Sciences, Université Henri Poincaré, BP 239, 54506 Vandoeuvre-Lès-Nancy, France victor.mamane@sor.uhp-nancy.fr
Abstract:
[Chemical reaction: see text] New chiral pyridine derivatives possessing the planar chirality of the ferrocene have been prepared by means of an aldolization-crotonization reaction. This very simple reaction has been applied to the synthesis of isomers 1-4 that differ in the position of the nitrogen atom on the pyridine ring. Following the same procedure, asymmetric synthesis of 1 has been achieved using an enantiopure ferrocenylzinc intermediate. This method has also allowed the preparation of a chiral analogue of 2,2'-bipyridine.
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