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Effect of atrazine on hemopoietic system
M Mencoboni1, R Lerza, G Bogliolo
1Dipartimento di Medicina Interna (DI.M.I.), Università di Genova, Italy.
In Vivo (Athens, Greece)
|January 1, 1992
Summary
Atrazine, an s-triazine herbicide, shows a hemotoxic effect by impacting mouse bone marrow progenitors and reticulocytes. While recovery was observed, further chronic exposure studies are needed.
Area of Science:
- Environmental Toxicology
- Hematology
- Pesticide Action
Background:
- Historical association of certain pesticides like DDT with bone marrow aplasia.
- Limited understanding of s-triazine herbicides' impact on hematopoiesis.
Purpose of the Study:
- To investigate the hemotoxic effects of atrazine, an s-triazine herbicide, on mouse hematopoietic system.
- To assess the impact of atrazine on hematopoietic progenitors (CFU-S, GM-CFC) and peripheral blood cells (leukocytes, reticulocytes).
Main Methods:
- Single intraperitoneal injection of atrazine (58.65 mg/kg) in mice.
- Evaluation of peripheral blood parameters (leukocytes, reticulocytes).
- Assessment of hematopoietic progenitor cell populations (CFU-S, GM-CFC).
Main Results:
- A severe but prompt drop in reticulocyte levels was observed post-atrazine exposure.
- Hematopoietic progenitors (CFU-S and GM-CFC) were significantly affected but showed recovery within days.
- Peripheral blood leukocyte counts remained unchanged.
Conclusions:
- Atrazine exhibits a clear hemotoxic effect on mouse hematopoietic progenitors and reticulocytes.
- The observed recovery suggests a potential for resilience, but further investigation into chronic exposure effects is warranted.