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Defining poor responders in assisted reproduction.
Hassan N Sallam1, Fathy Ezzeldin, Abdel-Fattah Agameya
1Departments of Obstetrics and Gynaecology, The University of Alexandria, Egypt.
International Journal of Fertility and Women'S Medicine
|November 11, 2005
Summary
Defining "poor responders" in assisted reproduction is crucial. This study found that fewer than 5, 6, or 8 oocytes retrieved during ICSI, IVF, or TeSE/ICSI, respectively, indicates poor response and diminished pregnancy rates.
Area of Science:
- Reproductive Medicine
- Infertility Research
- Assisted Reproductive Technology (ART)
Background:
- Defining
- poor responders
- is critical for optimizing assisted reproduction outcomes.
- Current definitions lack objective criteria, impacting treatment protocols.
- Establishing clear thresholds is essential for patient management.
Purpose of the Study:
- To establish an objective, evidence-based definition of
- poor responders
- in assisted reproduction.
- To correlate oocyte yield with clinical pregnancy rates across different ART modalities.
Main Methods:
- Retrospective analysis of data from 782 infertile couples undergoing ART.
- Simple linear regression to assess the relationship between oocytes retrieved and pregnancy rates.
- Receiver-operator characteristic (ROC) curve analysis to determine critical oocyte thresholds.
Main Results:
- A strong positive correlation (r = 0.90) was observed between oocyte retrieval numbers and clinical pregnancy rates.
- Significantly diminished pregnancy rates were noted when fewer than 5 oocytes (ICSI), 6 oocytes (IVF), or 8 oocytes (TeSE/ICSI) were retrieved.
Conclusions:
- The definition of
- poor responders
- in assisted reproduction is dependent on the specific treatment modality.
- Objective criteria are proposed: <5 oocytes for ICSI, <6 for IVF, and <8 for TeSE/ICSI.
- These definitions can guide clinical decision-making and improve patient counseling.