Related Experiment Video
Updated: Aug 1, 2026

Determining the Reactivity and Titre of Serum using a Haemagglutination Assay
Published on: January 29, 2010
Reactions between human serum gamma-globulin and zinc cations
S B Cheknev1, E E Babaeva, U A Vorobeva
1Laboratory of Cell-Cell Interactions, N. F. Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow. cheknev@riem.ru
Abstract:
Interactions of human serum gamma-globulin with zinc cations in solution were studied by differential spectrophotometry in UV light. Supraphysiological concentrations of zinc caused an increment in optical density of protein solution reflecting the effect of gamma-globulin saturation with the metal. Zinc concentrations below physiological led to hypochromism in the protein absorption spectrum. Conformation changes in gamma-globulin during interactions with zinc are analyzed for the surface and intramolecular binding sites and are compared with the effects of copper cations.
Related Concept Videos
Standard Electrode Potentials
EDTA: Auxiliary Complexing Reagents
Hypersensitivity Reactions: Cytolytic Reactions
Hypersensitivity Reactions: Immune-Complex Reactions

