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Updated: Aug 14, 2026

A Seminiferous Tubule Squash Technique for the Cytological Analysis of Spermatogenesis Using the Mouse Model
Published on: February 6, 2018
Carnosine-induced changes in the development of spermatogenic epithelial cells in senescence accelerated SAM mice
A V Gopko1, A Y Kulibin, M L Semenova
1Embryology Department, Biological Faculty, M. V. Lomonosov Moscow State University.
Abstract:
Carnosine significantly increased the number of spermatogonia and Sertoli cells in mice prone (SAMP1) and resistant (SAMR1) to accelerated aging and appreciably reduced cell yield in meiosis and spermiogenesis in SAMP1 mice. In experimental SAMP1 mice catastrophic changes in the number of gametes were paralleled by intensive degradation of the spermatogenic epithelium. In SAMR1 mice treated with carnosine highly ordered spermatogenic structure was preserved.
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