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Related Experiment Videos

High-density lipoprotein function recent advances.

Benjamin J Ansell1, Karol E Watson, Alan M Fogelman

  • 1Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Journal of the American College of Cardiology
|November 16, 2005
PubMed
Summary
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High-density lipoproteins (HDL) can shift from protective to harmful, promoting inflammation and cardiovascular risk. Assessing HDL

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Immunology

Background:

  • High-density lipoproteins (HDL) are typically associated with protection against atherosclerosis.
  • However, HDL can become proinflammatory under certain conditions, influencing vascular health.
  • Specific molecular changes in HDL impact its functional properties.

Purpose of the Study:

  • To investigate the functional shift of HDL from anti-inflammatory to proinflammatory.
  • To understand how HDL's composition affects its role in vascular inflammation, lipid oxidation, plaque growth, and thrombosis.
  • To explore novel methods for assessing HDL's functional capacity and cardiovascular risk.

Main Methods:

  • Utilizing cell-based and cell-free assays to evaluate HDL's anti-inflammatory and proinflammatory properties.

Related Experiment Videos

  • Examining the impact of systemic inflammation and metabolic syndrome on HDL functionality.
  • Investigating the effects of therapeutic agents like statins and apolipoprotein A-1 mimetics on HDL function.

    • Main Results:

    • Systemic inflammation and metabolic syndrome were found to induce a proinflammatory HDL phenotype.
    • Statins and apolipoprotein A-1 mimetics demonstrated the ability to promote an anti-inflammatory HDL profile.
    • HDL's functional capacity can be modulated by its protein and enzyme components.

    Conclusions:

    • Functional characterization of HDL offers a promising approach for improved cardiovascular risk assessment.
    • Understanding HDL's dual role in inflammation is crucial for developing targeted therapies.
    • Modulating HDL function represents a potential strategy for cardiovascular risk reduction.