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Phosphodiesterase-5 inhibition: the molecular biology of erectile function and dysfunction

Sharron H Francis1, Jackie D Corbin

  • 1Department of Molecular Physiology and Biophysics, Light Hall, Room 702, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA. sharron.francis@vanderbilt.edu

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Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

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Protein Kinases and Phosphatases

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Protein kinases
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Phosphodiester Linkages

Overview
Phosphodiester bond forms when a phosphoric acid molecule (H3PO4) links with two hydroxyl groups (–OH) of two other molecules, forming two ester bonds. Two water molecules are released in this process. The phosphodiester bond is commonly found in nucleic acids (DNA and RNA) and plays a critical role in their structure and function.
Phosphodiester Bonds Link Nucleotides Together
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Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

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Phosphoinositides and PIPs

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Nitric Oxide Signaling Pathway

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