Related Experiment Videos
New developments in topical sequential therapy for psoriasis.
1Department of Dermatology, School of Medicine, University of California at San Francisco, San Francisco, CA, USA.
Skin Therapy Letter
|November 18, 2005
Summary
Topical sequential therapy, using corticosteroids and calcipotriene, effectively treats psoriasis. This approach balances rapid lesion clearance with long-term remission, minimizing side effects for psoriasis patients.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical agents are standard for limited psoriasis ( <10% body surface area).
- Long-term efficacy of monotherapy can be limited.
- Psoriasis requires effective, well-tolerated long-term management strategies.
Purpose of the Study:
- To describe topical sequential therapy for psoriasis management.
- To highlight the benefits of combining corticosteroids and calcipotriene.
Main Methods:
- Topical sequential therapy involves three phases: clearance, transition, and maintenance.
- Utilizes a class I corticosteroid and calcipotriene.
- Application strategy tailored to disease phase.
Main Results:
- Achieves rapid clearance of psoriatic lesions.
- Provides effective long-term maintenance of remission.
- Balances therapeutic efficacy with minimized side effects.
Conclusions:
- Topical sequential therapy is an effective strategy for psoriasis.
- Offers a favorable risk-benefit profile for sustained disease control.
- Represents an accepted and widely practiced clinical technique.