Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial dysfunction after lactated Ringer's solution resuscitation for hemorrhagic shock.

Stephanie A Savage1, Colleen M Fitzpatrick, Vikram S Kashyap

  • 1Department of General Surgery, Wilford Hall Medical Center, Lackland AFB, Texas, USA.

The Journal of Trauma
|November 19, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometry-Aware Abdominal Aortic Aneurysm Digital Twin for Patient-Specific Wall Stress Mapping.

Research square·2026
Same author

National study to characterize teletrauma use in United States emergency departments.

Journal of telemedicine and telecare·2026
Same author

"Understanding the Effect of Transfusion Rates on Differential Modulation of Inflammatory Responses".

The Journal of surgical research·2026
Same author

American Association for the Surgery of Trauma/American College of Surgeons-Committee on Trauma Clinical Consensus Statement on the management of patients with rib fractures.

The journal of trauma and acute care surgery·2026
Same author

Forecasting Patient-Specific Abdominal Aortic Aneurysm Geometry with Mixed-Effects Models.

Diagnostics (Basel, Switzerland)·2026
Same author

Readiness Requires Repetition: Why Daily Trauma Care is the Foundation of Military Surge Capacity.

Journal of the American College of Surgeons·2026

Resuscitating hemorrhagic shock patients with lactated Ringer's solution (LR) alone causes endothelial dysfunction. Blood products like shed blood (SB) or LR with shed blood (LRSB) better preserve endothelial function and nitric oxide bioactivity.

Area of Science:

  • Physiology
  • Resuscitation Medicine
  • Vascular Biology

Background:

  • Endothelial dysfunction is a known complication following hemorrhagic shock and resuscitation.
  • A novel large-animal model was developed to investigate the impact of different resuscitation strategies on endothelial function.

Purpose of the Study:

  • To evaluate the effects of various resuscitation regimens on endothelial-dependent relaxation (EDR) after hemorrhagic shock.
  • To compare the efficacy of shed blood (SB), lactated Ringer's solution followed by shed blood (LRSB), and lactated Ringer's solution alone (LR) in preserving endothelial function.

Main Methods:

  • Hemorrhagic shock was induced in domestic pigs, followed by resuscitation with SB, LRSB, or LR.
  • Endothelial-dependent relaxation was measured using acetylcholine infusion and ultrasonography.

Related Experiment Videos

  • Endothelial-independent relaxation was assessed via sodium nitroprusside infusion.

    • Main Results:

    • LR resuscitation required significantly larger volumes compared to SB or LRSB.
    • LR resuscitation resulted in decreased endothelial-dependent relaxation at 1 and 4 hours post-resuscitation compared to SB and LRSB.
    • Serum nitric oxide levels were lower following LR resuscitation.

    Conclusions:

    • Lactated Ringer's solution alone leads to endothelial dysfunction after hemorrhagic shock.
    • Resuscitation with blood products (SB or LRSB) appears to preserve endothelial function and potentially nitric oxide bioactivity better than crystalloid resuscitation.
    • This large-animal model provides a platform for studying endothelial responses to different resuscitation strategies.