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Radiocolloid scans in evaluating splenic response to external radiation
Summary
The spleen is more resistant to radiation than previously thought, especially when affected by diseases other than chronic myelocytic leukemia. Spleen scans effectively document radiation response.
Area of Science:
- Nuclear medicine
- Radiology
- Oncology
Background:
- The spleen's response to external radiation is not fully understood.
- Assessing splenic function and size post-radiation is crucial for treatment monitoring.
Purpose of the Study:
- To evaluate the spleen's size and function after abdominal radiation therapy.
- To determine the radiation dose tolerance of the spleen in various conditions.
Main Methods:
- Utilized technetium-99m sulfur colloid for spleen imaging.
- Measured splenic size and liver/spleen radioactivity ratios.
- Analyzed serial scans in patients receiving varying radiation doses.
Main Results:
- Whole-abdominal radiation (approx. 2,000 R) did not cause splenic atrophy or alter liver/spleen ratios.
- 1,450 R splenic radiation showed no significant change in spleen length.
- Spleen size changes occurred only after 1,800 R in one patient.
- Normal splenic uptake persisted 5 years after 3,600 R.
Conclusions:
- The spleen, particularly when affected by diseases other than chronic myelocytic leukemia, demonstrates significant resistance to external radiation.
- Spleen scintigraphy is a valuable tool for documenting splenic response to radiation therapy.