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Autonomic cardiovascular reflexes in progressive supranuclear palsy
1Department of Neurology, Lahey Clinic Medical Center, Burlington, Massachusetts 01805.
Journal of the Autonomic Nervous System
|June 1, 1992
Summary
Autonomic nervous system dysfunction in progressive supranuclear palsy (PSP) is minor. Cardiovascular reflex testing revealed subtle differences in blood pressure and heart rate responses in PSP patients compared to controls.
Area of Science:
- Neurology
- Autonomic Neuroscience
Background:
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
- Autonomic nervous system (ANS) dysfunction can occur in neurodegenerative conditions.
Purpose of the Study:
- To assess autonomic nervous system (ANS) function in patients with progressive supranuclear palsy (PSP).
- To identify specific cardiovascular reflex abnormalities in PSP.
Main Methods:
- Cardiovascular reflex testing was performed on nine PSP patients and 15 age-matched controls.
- Tests included standing, sustained handgrip, cold pressor, Valsalva maneuver, and deep breathing.
Main Results:
- PSP patients showed a greater blood pressure drop on standing and diminished diastolic pressure rise during handgrip.
- Compensatory tachycardia upon standing (30:15 ratio) was reduced in PSP patients, linked to slow postural adjustment.
- No significant differences were found in cold pressor, Valsalva, or deep breathing tests.
Conclusions:
- Autonomic nervous system involvement in PSP is generally minor.
- Observed ANS dysfunction may stem from central brainstem sympathetic nuclei or efferent fiber involvement.