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Current advances in sustained-release systems for parenteral drug delivery
1Abbott Laboratories, Global Pharmaceutical Research & Development, Abbott Park, IL 60064, USA.
Expert Opinion on Drug Delivery
|November 22, 2005
Summary
Recent advancements in parenteral sustained-release systems, driven by new materials and fabrication methods, have led to successful product launches. These innovations specifically address challenges in delivering proteins and other biologics.
Area of Science:
- Pharmaceutical Sciences
- Biotechnology
- Materials Science
Background:
- Parenteral sustained-release systems have seen significant recent progress.
- Commercial success is attributed to novel carrier materials and fabrication techniques.
- Biologics present unique formulation challenges for sustained delivery.
Purpose of the Study:
- To review recent advancements in parenteral sustained-release systems.
- To focus on carrier systems and preparation methods for biologics.
- To highlight solutions for unmet needs in parenteral protein delivery.
Main Methods:
- Literature review of recent developments in parenteral drug delivery.
- Analysis of novel carrier materials and fabrication technologies.
- Examination of specific applications for protein and biologic delivery.
Main Results:
- Several new parenteral sustained-release products have been approved and launched.
- Novel materials and fabrication methods are key drivers of success.
- Specialized delivery systems are emerging for biologics, particularly proteins.
Conclusions:
- The field of parenteral sustained-release systems is rapidly advancing.
- Innovation in materials and manufacturing is crucial for product development.
- Tailored systems are essential to overcome challenges in parenteral biologic delivery.
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