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Frosta: a new technology for making fast-melting tablets
Seong Hoon Jeong1, Yourong Fu, Kinam Park
1Purdue University, Departments of Pharmaceutics and Biomedical Engineering, West Lafayette, IN 47907, USA.
Expert Opinion on Drug Delivery
|November 22, 2005
Summary
Frosta technology offers a cost-effective method for producing fast-melting tablets (FMTs) using conventional equipment. These robust, rapidly dissolving tablets enhance oral drug delivery for various applications.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Fast-melting tablet (FMT) technology is an innovative oral drug delivery system with growing applications.
- Existing FMT technologies have limitations, driving the need for improved methods.
Purpose of the Study:
- To introduce and evaluate the Frosta technology for producing fast-melting tablets.
- To assess the cost-effectiveness, mechanical properties, and stability of Frosta tablets.
Main Methods:
- Frosta technology utilizes conventional wet granulation and tablet pressing.
- Production employs standard rotary tablet presses without specialized instruments.
- Tablets were subjected to mechanical strength and accelerated stability testing.
Main Results:
- Frosta tablets exhibit mechanical strength with friability < 1% and stability under accelerated conditions.
- The technology allows for cost-effective production compared to other FMT methods.
- Frosta tablets demonstrate rapid melting (< 10 seconds) for easy oral administration.
Conclusions:
- Frosta technology provides a robust, stable, and cost-effective approach to FMT production.
- This innovation facilitates wider application of fast-melting tablets in drug and nutritional formulations.
- The use of conventional manufacturing processes makes Frosta technology highly accessible.