Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reactive arthritis.

Danielle Lauren Petersel1, Leonard H Sigal

  • 1Division of Rheumatology, Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, MEB484, PO Box 19, New Brunswick, NJ 08903-0019, USA.

Infectious Disease Clinics of North America
|November 22, 2005
PubMed
Summary

Reactive arthritis (ReA) involves joint inflammation, enthesitis, and other symptoms, often triggered by bacterial infections. While HLA-B27 is common, diagnosis relies on clinical evaluation, with NSAIDs and physiotherapy as standard treatments.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aspects of the Immunopathogenesis of Lyme Arthritis.

Microorganisms·2025
Same author

Proposed Immunopathogenetic Mechanisms Underlying Lyme Arthritis.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2024
Same author

Autobiographical Case Report: A Rubber Band, a Glass of Orange Juice.

Cureus·2021
Same author

What is causing the 'long-hauler' phenomenon after COVID-19?

Cleveland Clinic journal of medicine·2021
Same author

Enhanced Adhesion and OspC Protein Synthesis of the Lyme Disease Spirochete Borrelia Burgdorferi Cultivated in a Host-Derived Tissue Co-Culture System.

Balkan medical journal·2014
Same author

Basic science for the clinician 59: polymorphonuclear cells: mechanisms in human defense and in the pathogenesis of autoimmune disease.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2012

Area of Science:

  • Rheumatology
  • Immunology
  • Infectious Disease

Background:

  • Reactive arthritis (ReA) is characterized by sterile inflammation affecting joints, entheses, and extra-articular sites.
  • A significant proportion of patients with ReA test positive for the HLA-B27 genetic marker.
  • The condition is typically initiated by exposure to specific bacterial antigens.

Purpose of the Study:

  • To summarize the key features of reactive arthritis.
  • To outline diagnostic approaches and current therapeutic strategies.
  • To discuss the potential role of novel treatments in severe cases.

Main Methods:

  • Clinical examination and patient history are primary diagnostic tools.
  • Assessment of HLA-B27 status, though its clinical relevance in individual diagnosis is limited.

Related Experiment Videos

  • Review of current treatment modalities, including NSAIDs, physiotherapy, and emerging biologic therapies.

    • Main Results:

    • Diagnosis of ReA is primarily clinical, supported by patient history.
    • While HLA-B27 positivity is frequent, it is not essential for diagnosis.
    • Standard treatment involves NSAIDs and physiotherapy, with molecular biologics showing promise for severe cases.

    Conclusions:

    • Reactive arthritis is a distinct clinical entity with characteristic inflammatory patterns.
    • Diagnosis relies heavily on clinical assessment and historical factors.
    • Current treatments are effective for many, but advanced therapies are needed for refractory ReA.