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Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
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Crosslinked chitosan--preparation and characterization
Keelara V Harish Prashanth1, Rudrapatnam N Tharanathan
1Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore 570020, India.
Carbohydrate Research
|November 22, 2005
Summary
Chitosan depolymerization and crosslinking occur with potassium persulfate. This process induces conformational changes and increases crystallinity in the modified chitosan material.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomaterials
Background:
- Chitosan is a versatile biopolymer with potential applications in various fields.
- Understanding chitosan's behavior under different chemical and thermal conditions is crucial for its effective utilization.
Purpose of the Study:
- To investigate the radical-induced depolymerization of chitosan.
- To explore the subsequent crosslinking and structural changes of chitosan.
- To analyze the impact of these processes on chitosan's crystallinity.
Main Methods:
- Chitosan treatment with potassium persulfate at 60°C.
- Controlled cooling to 4°C for crosslinking.
- Analysis of structural and conformational changes using Infrared (IR) spectroscopy, X-ray diffraction, and Carbon-13 Nuclear Magnetic Resonance (13C NMR).
Main Results:
- Radical-induced depolymerization of chitosan was achieved.
- Extensive crosslinking of fragmented chitosan chains occurred upon cooling.
- Evidence of a conformational change leading to increased crystallinity was observed via IR, X-ray, and 13C NMR.
Conclusions:
- Potassium persulfate effectively induces depolymerization and subsequent crosslinking in chitosan.
- The observed conformational changes result in enhanced crystallinity of the modified chitosan.
- This study provides insights into tailoring chitosan's structure and properties for advanced applications.
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