Cell population dynamics modulate the rates of tissue growth processes
Gang Cheng1, Belgacem B Youssef, Pauline Markenscoff
1Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77251-1892, USA.
Biophysical Journal
|November 22, 2005
Summary
This study presents a discrete model for tissue growth in scaffolds. Cell migration and seeding distribution significantly impact tissue regeneration rates, guiding future biomimetic design.
Area of Science:
- Biomedical Engineering
- Computational Biology
- Tissue Engineering
Background:
- Tissue growth in scaffolds is crucial for regenerative medicine.
- Understanding cell dynamics, including migration and proliferation, is key to optimizing engineered tissues.
- Existing models often simplify cell behavior, necessitating more detailed simulations.
Purpose of the Study:
- To develop and test a discrete model for dynamic tissue growth in 3D scaffolds.
- To investigate the influence of cell migration and spatial distribution on tissue regeneration.
- To isolate the effects of cell population dynamics under constant nutrient conditions.
Main Methods:
- Developed a discrete model simulating cell populations on a computational grid.
- Modeled cell behavior including persistent random walks, collisions, and proliferation.
- Simulated tissue growth with uniform random seeding and a wound-healing-inspired initial condition.
Main Results:
- Cell migration enhances tissue growth by mitigating contact inhibition in uniformly seeded scaffolds.
- The beneficial effect of migration diminishes at higher speeds.
- Regeneration rates continually increase with migration speed in wound-simulating conditions.
Conclusions:
- Cell locomotory parameters and initial spatial distribution profoundly affect tissue growth dynamics.
- Model results can inform experimental design for biomimetic modifications to stimulate tissue growth.
- Optimizing cell migration and seeding strategies is critical for effective tissue engineering.
More Related Videos
10:24Generation of Heterogeneous Drug Gradients Across Cancer Populations on a Microfluidic Evolution Accelerator for Real-Time Observation
Published on: September 19, 2019
11:41Real Time and Repeated Measurement of Skeletal Muscle Growth in Individual Live Zebrafish Subjected to Altered Electrical Activity
Published on: June 16, 2022
Related Concept Videos
02:36Cells Coordinate Growth and Proliferation
Cell size is a significant factor impacting cellular design, function, and fitness. There exists some internal coordination by which cells double their masses before division, thus, achieving homeostasis. Coordination between cell growth and proliferation depends on the checkpoints in between cell cycle phases. Loss of coordination or failure in the checkpoint mechanism can drive the cell to uncontrolled growth and loss of cellular function. Like dividing cells that coordinate cellular growth,...
02:53Adaptive Mechanisms in Cancer Cells
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
01:26Stem Cell Niche
The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
01:23Tissue Renewal without Stem Cells
After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
However, failure of such a system...
01:29Exponential Growth
Bacterial populations exhibit exponential growth when conditions such as nutrient availability and temperature are favorable. In this phase, cells reproduce through binary fission, where each cell divides into two identical daughter cells. This process causes the population to double at regular intervals, resulting in a growth rate that is directly proportional to the current number of cells. As the population increases, the number of new cells formed during each generation also grows, creating...
01:26Cellular Adaptation III: Hyperplasia
Hyperplasia is an increase in the number of cells in a tissue or organ due to enhanced cell division. It is an adaptive, controlled response to stimuli such as injury, hormones, or stress, involving mitosis to produce genetically identical cells and support tissue repair and regeneration.Tissue CapacityCertain tissues, including the epidermis, intestinal epithelium, bone marrow, and fibroblasts, have a high potential for hyperplasia. Others, such as bone, cartilage, and smooth muscle, show...