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Risk factors and underlying cardiovascular diseases in incident ESRD patients

Attilio Di Benedetto1, Daniele Marcelli, Antonello D'Andrea

  • 1NephroCare Medical Direction, Fresenius Medical Care Italy, Naples--Italy. attilio.dibenedetto@fmc-ag.com

Journal of Nephrology
|November 22, 2005
PubMed

Insights

Cardiovascular disease (CVD) is common in dialysis patients, with high rates of risk factors like diabetes and smoking at admission. Many patients develop new CVD events during treatment, highlighting the need for better management.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) is the primary cause of death and illness in patients undergoing dialysis.
  • Evaluating cardiovascular risk factors and CVD prevalence upon initiation of hemodialysis is crucial.

Purpose of the Study:

  • To determine the prevalence of cardiovascular risk factors and existing CVD in patients starting hemodialysis.
  • To assess the incidence of new-onset CVD events during hemodialysis treatment.

Main Methods:

  • Prospective data collection from 636 patients across 31 Italian dialysis clinics between 2000 and 2003.
  • Patients were categorized based on the presence of CVD at baseline and followed for a median of 16 months.
  • Logistic regression analysis identified traditional and non-traditional risk factors associated with CVD.

Main Results:

  • At hemodialysis admission, 27% of patients had pre-existing CVD.
  • Smoking and diabetes were significantly associated with a higher risk of prevalent CVD (OR 1.87 for both).
  • The incidence rate of de novo CVD events was 3.70 per 100 patient-years, with diseases of arteries/arterioles being most common.

Conclusions:

  • Dialysis patients exhibit a high burden of cardiovascular risk factors upon starting treatment.
  • A significant number of patients develop new cardiovascular events despite ongoing dialysis care.
Abstract

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