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Related Experiment Videos

REDfly: a Regulatory Element Database for Drosophila.

Steven M Gallo1, Long Li, Zihua Hu

  • 1Center for Computational Research, 140 Farber Hall, State University of New York at Buffalo, 3435 Main Street, Buffalo, NY 14214, USA.

Bioinformatics (Oxford, England)
|November 24, 2005
PubMed
Summary

Researchers created a database of Drosophila cis-regulatory modules (CRMs) to aid bioinformatics studies. This resource provides DNA sequences and gene expression data, improving CRM discovery and analysis.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Developmental Biology

Background:

  • Bioinformatics research on metazoan transcriptional regulation is limited by a lack of data on cis-regulatory modules (CRMs).
  • Even the well-annotated Drosophila melanogaster genome has insufficient information on CRMs.

Purpose of the Study:

  • To present a curated database of Drosophila CRMs.
  • To facilitate computational approaches for CRM discovery and bioinformatics analyses.

Main Methods:

  • Literature curation of Drosophila cis-regulatory modules (CRMs).
  • Inclusion of DNA sequences and gene expression patterns for each CRM.

Main Results:

  • A comprehensive database of Drosophila CRMs has been established.

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  • The database includes DNA sequences and descriptions of regulated gene expression patterns.

    • Conclusions:

    • The Drosophila CRM database will significantly advance computational CRM discovery.
    • This resource will support bioinformatics analyses of regulatory sequence properties and evolution.