Image-directed fine needle aspiration biopsy in nonpalpable breast lesions

Fine needle aspiration biopsy of nonpalpable breast lesions may be performed with imaging guidance. The technique has a potential role, but is underused because of a relative paucity of specialty-trained, enthusiastic breast cytopathologists. This article discusses the strengths and limitations of the technique in the context of the various imaging modalities, and in comparison with needles used for histologic sampling.