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Wobenzym in treatment of recurrent obstructive bronchitis in children

N Lanchava1, K Nemsadze, I Chkhaidze

  • 1Tbilisi State Medical University; M. Guramishvili Pediatric Clinic, Tbilisi, Georgia.

Georgian Medical News
|November 26, 2005
PubMed

Insights

Wobenzym, a systemic enzyme preparation, improved lung function and reduced symptoms in children with recurrent obstructive bronchitis. This treatment showed promise as a supportive therapy for managing this condition.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Pharmacology

Background:

  • Recurrent obstructive bronchitis (ROB) affects children aged 5-15 years, characterized by at least three episodes annually.
  • Management of ROB often involves combination therapies to alleviate symptoms and improve pulmonary function.
  • Systemic enzyme preparations are explored for their potential anti-inflammatory and immunomodulatory effects.

Purpose of the Study:

  • To evaluate the efficacy of the systemic enzyme preparation Wobenzym as an adjunctive treatment for recurrent obstructive bronchitis in children.
  • To assess the impact of Wobenzym on clinical symptoms and pulmonary function indices in pediatric patients with ROB.

Main Methods:

  • A study involving 27 pediatric patients (5-15 years) diagnosed with recurrent obstructive bronchitis.
  • Serum IgE levels were measured using ELISA, alongside comprehensive pulmonary function tests (spirometry).
  • Patients received Wobenzym at a dosage of 1 tablet per 6 kg body weight for 3 months, with effectiveness assessed via a symptom questionnaire.

Main Results:

  • Treatment with Wobenzym led to a significant decrease in the Daily Symptom Score.
  • An increase in Symptom Free Days was observed post-treatment.
  • Spirometric indices, including Forced Vital Capacity (FVC), Forced Expiratory Volume (FEV), and Peak Expiratory Flow (PEF), showed improvement.

Conclusions:

  • Systemic enzyme preparation Wobenzym demonstrates effectiveness as a supportive measure in the combination treatment of recurrent obstructive bronchitis in children.
  • Wobenzym may help improve clinical outcomes and lung function in pediatric patients suffering from recurrent obstructive bronchitis.

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