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Published on: November 29, 2024

Decreased survival in diabetic patients with heart failure due to systolic dysfunction

Masoor Kamalesh1, Usha Subramanian, Stephen Sawada

  • 1Krannert Institute of Cardiology and VA Medical Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA. masoor.kamalesh@med.va.gov

European Journal of Heart Failure
|November 29, 2005
PubMed

Insights

Diabetic patients with heart failure (HF) have higher mortality rates than non-diabetic patients, even with recent therapeutic advancements. This prospective study confirms diabetes remains a significant risk factor for death in HF patients.

Area of Science:

  • Cardiology
  • Diabetology
  • Clinical Medicine

Background:

  • Heart failure (HF) prognosis has improved with new therapies.
  • The impact of these advances on diabetic HF patients in clinical practice remains unclear.
  • Prospective studies are needed to evaluate diabetic HF patient outcomes.

Purpose of the Study:

  • To prospectively investigate the prognosis of diabetic patients with heart failure (HF) and left ventricular systolic dysfunction.
  • To compare mortality rates between diabetic and non-diabetic HF patients.
  • To identify predictors of mortality in this population.

Main Methods:

  • Prospective enrollment of 495 HF patients with systolic dysfunction from October 1999 to November 2000.
  • Data collection via electronic medical records, including comorbidities, medications, and echocardiograms.
  • Mean follow-up duration of 2.7 years for mortality assessment.

Main Results:

  • 59% of enrolled HF patients had diabetes (293/495).
  • Diabetic patients showed higher rates of hypertension and diuretic use.
  • Mortality was significantly higher in the diabetic group (37%) compared to the non-diabetic group (24%).
  • Independent predictors of death included diabetes, age, serum creatinine, and diuretic use.

Conclusions:

  • Diabetic patients with heart failure experience higher mortality rates than non-diabetic patients.
  • Despite advances in HF therapy, diabetes remains a significant adverse prognostic factor.
  • Further research may be needed to optimize HF management in diabetic populations.
Abstract

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