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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
[Preparation and investigation of gemfibrozil + dimethyl-beta-cyclodextrin products and solid dosage forms]
Bin Hassan Hassan1, Zoltán Aigner, Péter Kása
1Szegedi Tudományegyetem, Gyógyszer-technológiai Intézet, Szeged, Eötvös u. 6. - 6720.
Abstract:
Gemfibrozil is a lipid-regulating active substance. Dimethyl-beta-cyclodextrin products were prepared from this sparingly soluble pharmacon by means of methods such as physical mixing, kneading, spray drying and ultrasonication. Solid dosage forms (hydroxypropylmethyl cellulose /HPMC/ capsules and tablets) were prepared from the selected products on the basis of their dissolution profile and the in vitro membrane diffusion results. This publication details the results of electronmicroscopic morphological studies, particle size analysis and wetting contact angle determinations, and also the preparation and examination of the resulting solid dosage forms.
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