Cardiac isoform of alpha-2 macroglobulin as a novel diagnostic marker for cardiac diseases
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Updated: Aug 14, 2026

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay
Published on: August 8, 2013
Andiappan Rathinavel1, Perundurai S Dhandapany, Ponnambalam Annapoorani
1Department of Cardio-Thoracic Surgery, Madurai Medical College and Government Rajaji Hospital, Madurai, Tamil Nadu, India. biochemselvam@rediffmail.com
Background:
Earlier we showed cardiac isoform of alpha-2 macroglobulin (CA2M) to be an early marker of cardiac hypertrophy.
Design:
In this study, we tried to explore the possibility of using this protein as a marker for diagnosis of cardiac diseases.
Methods:
A total of 593 samples were analyzed for the presence of CA2M using sandwich enzyme-linked immunosorbent assay.
Results:
Samples include various cardiac diseases (230), non-cardiac ailments (263) and controls (100).
Conclusion:
Levels of CA2M in cardiac diseases were significantly higher than other sample groups but moderately elevated in leprosy. This protein could be considered for diagnosis of cardiac diseases as a serum marker.
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