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Updated: Aug 14, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
09:31

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Antiangiogenic therapies for mesothelioma

Jonathan E Dowell1, Hedy Lee Kindler

  • 1University of Texas-Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8852, USA. jonathan.dowell@utsouthwestern.edu

Hematology/Oncology Clinics of North America
|December 6, 2005
PubMed

Insights

Preclinical studies show angiogenesis is crucial in malignant mesothelioma development. Clinical trials investigating anti-angiogenesis agents in mesothelioma patients are underway, with preliminary results detailed herein.

Area of Science:

  • Oncology
  • Cancer Biology
  • Vascular Biology

Background:

  • Malignant mesothelioma pathogenesis involves angiogenesis.
  • Angiogenesis mediators act as autocrine growth factors in mesothelioma.
  • Preclinical models demonstrate tumor regression with anti-angiogenesis agents.

Purpose of the Study:

  • To review the role of angiogenesis in malignant mesothelioma.
  • To detail preliminary results from clinical trials of anti-angiogenesis inhibitors in mesothelioma.
  • To discuss future directions for anti-angiogenesis therapies in mesothelioma.

Main Methods:

  • Review of preclinical evidence on angiogenesis in mesothelioma.
  • Analysis of preliminary data from ongoing clinical trials evaluating anti-angiogenesis agents.
  • Synthesis of current research and future outlook.

Main Results:

  • Preclinical data strongly support angiogenesis's role in mesothelioma.
  • Clinical trials are actively assessing the efficacy of angiogenesis inhibitors.
  • Early findings from these trials are presented.

Conclusions:

  • Angiogenesis is a critical target for malignant mesothelioma treatment.
  • Ongoing clinical trials are evaluating novel anti-angiogenesis strategies.
  • Further research and clinical development are warranted.

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