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Related Experiment Videos

[Laboratory on a microfluidic chip].

Bingcheng Lin1, Jianhua Qin

  • 1Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China. bclin@dicp.ac.cn

Se Pu = Chinese Journal of Chromatography
|December 15, 2005
PubMed
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This review highlights advancements in microfluidic chip technology for complex analyses. Novel materials, integrated systems, and single-molecule detection enable sensitive protein analysis, drug screening, and disease diagnostics.

Area of Science:

  • Microfluidics and Lab-on-a-Chip Technology
  • Analytical Chemistry
  • Biotechnology

Context:

  • Microfluidic chip fabrication has advanced, enabling complex designs in diverse materials like quartz, PMMA, and PDMS.
  • Surface modification techniques enhance reproducibility and efficiency for protein and peptide analysis.
  • Novel materials for chip fabrication are under active investigation.

Purpose:

  • To review recent achievements and applications of microfluidic chips developed in the authors' laboratory.
  • To showcase the integration of microfluidic systems with advanced detection modules (LIF, UV, electrochemical, chemiluminescence).
  • To demonstrate the development of single-cell/single-molecule imaging systems for dynamic molecular and cellular event analysis.

Summary:

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  • Integrated microfluidic devices facilitate complex analyses, including glycoform separation, coupled isotachophoresis (ITP) and electrophoresis for enhanced protein sensitivity (50-fold increase).
  • Single-molecule detection (SMD) techniques enable precise measurement of flow velocities and observation of molecular interactions.
  • Applications include ultra-rapid determination of intracellular reactive oxygen species (ROS) and reduced glutathione (GSH), drug screening, and disease diagnostics (SARS, cancer, hypertension).

    • Impact:

    • Microfluidic platforms offer high sensitivity and efficiency for protein and peptide analysis.
    • The developed systems support advanced drug screening and personalized medicine through detailed molecular and cellular interaction studies.
    • Microfluidic chip electrophoresis (MCE) aids in rapid and sensitive disease diagnosis and genetic polymorphism analysis.