Related Experiment Video
Updated: Aug 14, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
Published on: May 8, 2015
Sequence-encoded self-assembly of multiple-nanocomponent arrays by 2D DNA scaffolding
Yariv Y Pinto1, John D Le, Nadrian C Seeman
1Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
Abstract:
Regular 2D arrays of multiple types of nanocomponents were constructed by self-assembly to DNA scaffolding with alternating rows of sequence-encoded hybridization sites. Different-sized Au particles coated with DNA complementary to one of the sites were bound to the scaffolding, producing alternating rows of the two nanocomponents with a 32-nm inter-row spacing. These results demonstrate the potential for using DNA to self-assemble complex arrays of components with nanometer-scale precision.
Related Concept Videos
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
DNA as a Genetic Template
DNA Packaging
Genome Annotation and Assembly
Assembly of Cytoskeletal Filaments
Genomic DNA in Eukaryotes

