Related Experiment Videos
BSB: a new mouse model of multigenic obesity
J S Fisler1, C H Warden, M J Pace
1Department of Medicine, University of California, Los Angeles, CA 90024, USA.
Obesity Research
|July 1, 1993
Summary
A new mouse model, BSB mice, exhibits multigenic obesity due to multiple genes. This model is valuable for studying obesity
Area of Science:
- Genetics
- Animal Models
- Metabolic Research
Background:
- Obesity is a complex, multifactorial trait influenced by numerous genes.
- Existing animal models may not fully capture the genetic complexity of human obesity.
Purpose of the Study:
- To develop and characterize a novel mouse model for the genetic analysis of multigenic obesity.
- To investigate the associated metabolic phenotypes in this new model.
Main Methods:
- Generation of backcross progeny (BSB mice) from C57BL/6J and Mus spretus strains.
- Phenotypic characterization of body fat percentage, fat distribution, and metabolic markers.
- Assessment of plasma corticosterone levels.
Main Results:
- BSB mice display a wide range of body fat (1-50%), indicating polygenic inheritance.
- Obesity is associated with increased intra-abdominal and subcutaneous fat, hyperinsulinemia, hyperglycemia, and hyperlipidemia.
- Obese BSB mice show reduced stimulated plasma corticosterone levels, irrespective of sex.
Conclusions:
- The BSB mouse model is a valuable tool for dissecting the genetic architecture of obesity.
- This model facilitates the study of multifactorial obesity and its related metabolic disorders.
- BSB mice provide a platform for identifying genes contributing to obesity and associated phenotypes.