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[Antibiotics in laryngectomized patients: prophylactic use in the postoperative period]
1Universidad de Antioquía, Medellín, Colombia.
Insights
Prophylactic sodium cefoperazone significantly reduced surgical site infections in laryngectomees compared to penicillin/gentamycin. Further analysis is needed as the infection rate remains high.
Area of Science:
- Infectious Diseases
- Surgical Oncology
- Pharmacology
Context:
- Post-operative infections are a significant concern in laryngectomy patients.
- This study evaluated antibiotic prophylaxis in a Colombian hospital setting.
Purpose:
- To compare the efficacy of prophylactic sodium cefoperazone versus penicillin/gentamycin in preventing surgical site infections after laryngectomy.
- To identify factors influencing post-operative infection rates.
Summary:
- A follow-up study of 43 laryngectomees compared prophylactic sodium cefoperazone (n=20) with penicillin/gentamycin (n=23).
- The sodium cefoperazone group had a 16% infection index versus 65% in the penicillin/gentamycin group.
- Surgical duration, prior tracheotomy, cancer stage, neck dissection, and radiotherapy did not correlate with infection.
Impact:
- Sodium cefoperazone demonstrates superior efficacy in reducing post-laryngectomy infections.
- Despite improvements, infection rates necessitate further investigation into causative factors and optimal prophylactic strategies.
Abstract:
Study of the follow-up of 43 laryngectomees during a 20 months term done at the Hospital de San Vicente de Paul, Medellín, Colombia. Twenty patients received prophylactically 1 gr of sodium cefoperazone each 12 hours for 3 doses; the other 23 were treated with penicillin/gentamycin after surgery, for 10 days. Sodium cefoperazone group showed an infection index of 16 percent compared with 65 percent of the penicillin-gentamycin group. Factors such surgical time, previous tracheotomy, cancer staging, radical neck dissection and radiotherapy were not related to the infection. Index 16 percent still is high and possible responsible causes are analyzed in the paper.