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Flow-mediated dilation in patients with left ventricular diastolic dysfunction

T Chigogidze1, G Simonia

  • 1Department of Internal Medicine, Tbilisi State Medical University.

Georgian Medical News
|December 22, 2005
PubMed

Insights

Endothelial dysfunction, indicated by reduced flow-mediated dilation (FMD), is present in patients with left ventricular diastolic dysfunction (LVDD). This FMD decrease may signal early-stage LVDD in coronary artery disease and hypertension patients.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Diabetology

Background:

  • Left ventricular diastolic dysfunction (LVDD) is a significant clinical condition.
  • Endothelial dysfunction is implicated in various cardiovascular diseases.
  • Early detection of LVDD is crucial for timely intervention.

Purpose of the Study:

  • To evaluate endothelium-dependent flow-mediated dilation (FMD) of the brachial artery in patients with LVDD.
  • To compare FMD in patients with LVDD due to coronary artery disease (CAD) and essential hypertension versus controls without LVDD.
  • To assess the correlation between FMD and post-isosorbide dinitrate (ISDN) vasodilation.

Main Methods:

  • Assessed FMD in 36 male patients with LVDD (22 with CAD, 14 with hypertension) and 18 male controls without LVDD.
  • Utilized brachial artery ultrasound to measure FMD.
  • Measured post-ISDN vasodilation to assess nitric oxide-independent vasodilation.

Main Results:

  • Patients with LVDD exhibited significantly decreased FMD compared to controls (4.67% vs. 6.12%, p<0.05).
  • FMD was significantly lower in both patient groups than in healthy subjects.
  • Post-ISDN vasodilation was similar between LVDD groups and lower than controls, showing no difference based on LVDD presence or cause.

Conclusions:

  • Endothelial dysfunction is evident in patients with diastolic dysfunction.
  • Depressed FMD may serve as an indicator of early-stage LVDD in patients with CAD and arterial hypertension.
  • FMD assessment is a valuable tool for identifying endothelial dysfunction associated with LVDD.

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